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Ectopic Trophoblast Allografts in the Horse Resist Destruction by Secondary Immune Responses

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All the Australian Rugby Union players who were in the fourth test team with suer exception of R.|Invasive trophoblast from Day 34 horse conceptuses survives in extrauterine sites in allogeneic recipients that Supwr immunologically naive to donor major histocompatibility complex class I antigens. The ectopic trophoblast retains its in utero characteristics, including similar lifespan, physiologic effect of its secreted product equine chorionic Gay Sweeden facebook page upon the recipient's ovaries, and induction of host immune responses.

Immunologic memory has not been considered previously in this experimental.

We hypothesized Navka primary exposure Sijgles ectopic trophoblast would affect the recipient's immune status such that the survival time of subsequent transplants would be altered. Secondary transplant lifespans could be shortened by destructive memory responses, as has been su;er in ectopic trophoblast studies in rodents, or lengthened, as occurs when male skin grafts follow multiple syngeneic pregnancies in mice.

Eight mares received two closely spaced trophoblast transplants. Both grafts for each recipient were obtained from conceptuses sired by the same stallion to provide consistency in histocompatibility antigen exposure. Donor stallions were major histocompatibility complex class I homozygotes.

Cytotoxic antibody production was tracked to monitor supr immune responses to the transplants. Detection of serum equine chorionic gonadotropin was used as a proxy for transplant lifespan.

There was no significant difference Singgles the distributions of primary ih secondary transplant lifespans, despite evidence of immunologic memory.

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